The recent Indonesian shrimp radiation occurrence is a good example of how the international seafood supply chain can affect the whole world. Whether the product is fish, shellfish, caviar, or octopus, the legal, regulatory, and compliance requirements for the companies responsible for aquaculture farming, catching, cleaning, sanitizing, cold chain transportation, and declaration to customs authorities at the country of importation are critical and complex. Knowing, understanding, and complying with the set of requirements for the international supply chain, especially for seafood, is a challenge for the marketplace. There are numerous, significant changes in laws, regulations, policies, and procedures that directly affect those companies involved in the international supply chain. Personnel from companies that are aware of these new changes will have an economic advantage, and avoid business and legal mishaps.